Staff profile

Journal Article

• Moya-Molina, M., Dorgau, B., Flood, E., Letteboer, S. J. F., Lorentzen, E., Coxhead, J., Smith, G., Roepman, R., Nagaraja Grellscheid, S., Armstrong, L., & Lako, M. (2024). Deciphering the impact of PROM1 alternative splicing on human photoreceptor development and maturation. Cell Death and Disease, 15(10), Article 721. https://doi.org/10.1038/s41419-024-07105-7
• Atkinson, R., Georgiou, M., Yang, C., Szymanska, K., Lahat, A., Vasconcelos, E. J. R., Ji, Y., Moya Molina, M., Collin, J., Queen, R., Dorgau, B., Watson, A., Kurzawa-Akanbi, M., Laws, R., Saxena, A., Shyan Beh, C., Siachisumo, C., Goertler, F., Karwatka, M., Davey, T., …Lako, M. (2024). PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects. Nature Communications, 15(1), Article 3138. https://doi.org/10.1038/s41467-024-47253-0
• Law, J. O., Jones, C. M., Stevenson, T., Williamson, T. A., Turner, M. S., Kusumaatmaja, H., & Grellscheid, S. N. (2023). A bending rigidity parameter for stress granule condensates. Science Advances, 9(20), https://doi.org/10.1126/sciadv.adg0432
• Thompson, H., Shen, W., Matus, R., Kakkar, M., Jones, C., Dolan, D., Grellscheid, S., Yang, X., Zhang, N., Mozaffari-Jovin, S., Chen, C., Zhang, X., Topping, J., & Lindsey, K. (2023). MERISTEM-DEFECTIVE regulates the balance between stemness and differentiation in the root meristem through RNA splicing control. Development, 150(7), Article dev201476. https://doi.org/10.1242/dev.201476
• Abbas, M., Law, J. O., Grellscheid, S. N., Huck, W. T., & Spruijt, E. (2022). Peptide‐Based Coacervate‐Core Vesicles with Semipermeable Membranes. Advanced Materials, 34(34), Article 2202913. https://doi.org/10.1002/adma.202202913
• O’Hare, C. A., Matsos, V. G., Newton, J., Smith, K., Hochstetter, J., Jaiswar, R., Kyaw, W., McNamara, A., Kuncic, Z., Grellscheid, S. N., & Bœhm, C. (2022). Particle detection and tracking with DNA. The European Physical Journal C, 82(4), Article 306. https://doi.org/10.1140/epjc/s10052-022-10264-6
• Lagnado, A., Leslie, J., Ruchaud‐Sparagano, M., Victorelli, S., Hirsova, P., Ogrodnik, M., Collins, A. L., Vizioli, M. G., Habiballa, L., Saretzki, G., Evans, S. A., Salmonowicz, H., Hruby, A., Geh, D., Pavelko, K. D., Dolan, D., Reeves, H. L., Grellscheid, S., Wilson, C. H., Pandanaboyana, S., …Passos, J. F. (2021). Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner. The EMBO Journal, 40(9), Article e106048. https://doi.org/10.15252/embj.2020106048
• Chyżyńska, K., Labun, K., Jones, C., Grellscheid, S. N., & Valen, E. (2021). Deep conservation of ribosome stall sites across RNA processing genes. NAR Genomics and Bioinformatics, 3(2), https://doi.org/10.1093/nargab/lqab038
• Vietri, M., Schultz, S. W., Bellanger, A., Jones, C. M., Petersen, L. I., Raiborg, C., Skarpen, E., Pedurupillay, C. R. J., Kjos, I., Kip, E., Timmer, R., Jain, A., Collas, P., Knorr, R. L., Grellscheid, S. N., Kusumaatmaja, H., Brech, A., Micci, F., Stenmark, H., & Campsteijn, C. (2020). Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation. Nature Cell Biology, 22(7), 856-867. https://doi.org/10.1038/s41556-020-0537-5
• da Silva, P. F., Ogrodnik, M., Kucheryavenko, O., Glibert, J., Miwa, S., Cameron, K., Ishaq, A., Saretzki, G., Nagaraja-Grellscheid, S., Nelson, G., & von Zglinicki, T. (2019). The bystander effect contributes to the accumulation of senescent cells in vivo. Aging Cell, 18(1), Article e12848. https://doi.org/10.1111/acel.12848
• Ehrmann, I., Crichton, J. H., Gazzara, M. R., James, K., Liu, Y., Grellscheid, S. N., Curk, T., de Rooij, D., Steyn, J. S., Cockell, S., Adams, I. R., Barash, Y., & Elliott, D. J. (2019). An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning. eLife, 8, Article e39304. https://doi.org/10.7554/elife.39304
• Mellough, C. B., Bauer, R., Collin, J., Dorgau, B., Zerti, D., Dolan, D. W., Jones, C. M., Izuogu, O. G., Yu, M., Hallam, D., Steyn, J. S., White, K., Steel, D. H., Santibanez-Koref, M., Elliott, D. J., Jackson, M. S., Lindsay, S., Grellscheid, S., & Lako, M. (2019). An integrated transcriptional analysis of the developing human retina. Development, 146(2), Article dev169474. https://doi.org/10.1242/dev.169474
• Buskin, A., Zhu, L., Chichagova, V., Basu, B., Mozaffari-Jovin, S., Dolan, D., Droop, A., Collin, J., Bronstein, R., Mehrotra, S., Farkas, M., Hilgen, G., White, K., Pan, K.-T., Treumann, A., Hallam, D., Bialas, K., Chung, G., Mellough, C., Ding, Y., …Lako, M. (2018). Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nature Communications, 9(1), Article 4234. https://doi.org/10.1038/s41467-018-06448-y
• Lobine, D., Cummins, I., Govinden-Soulange, J., Ranghoo-Sanmukhiya, M., Lindsey, K., Chazot, P., Ambler, C., Grellscheid, S., Sharples, G., Lall, N., Lambrechts, I., Lavergne, C., & Howes, M.-J. (2018). Medicinal Mascarene Aloe s: An audit of their phytotherapeutic potential. Fitoterapia, 124, 120-126. https://doi.org/10.1016/j.fitote.2017.10.010
• Ogrodnik, M., Miwa, S., Tchkonia, T., Tiniakos, D., Wilson, C. L., Lahat, A., Day, C. P., Burt, A., Palmer, A., Anstee, Q. M., Grellscheid, S. N., Hoeijmakers, J. H., Barnhoorn, S., Mann, D. A., Bird, T. G., Vermeij, W. P., Kirkland, J. L., Passos, J. F., von Zglinicki, T., & Jurk, D. (2017). Cellular senescence drives age-dependent hepatic steatosis. Nature Communications, 8, https://doi.org/10.1038/ncomms15691
• Ghosh, P., Grellscheid, S. N., & Sowdhamini, R. (2016). A tale of two paralogs: human Transformer2 proteins with differential RNA-binding affinities. Journal of Biomolecular Structure and Dynamics, 34(9), 1979-1986. https://doi.org/10.1080/07391102.2015.1100551
• Feracci, M., Foot, J. N., Grellscheid, S. N., Danilenko, M., Stehle, R., Gonchar, O., Kang, H.-S., Dalgliesh, C., Meyer, N. H., Liu, Y., Lahat, A., Sattler, M., Eperon, I. C., Elliott, D. J., & Dominguez, C. (2016). Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68. Nature Communications, 7, Article 10355. https://doi.org/10.1038/ncomms10355
• Holly, A., Grellscheid, S., van de Walle, P., Dolan, D., Pilling, L., Daniels, D., von Zglinicki, T., Ferrucci, L., Melzer, D., & Harries, L. (2015). Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts. Biogerontology, 16, 423–434. https://doi.org/10.1007/s10522-015-9560-5
• Thien, A., Prentzell, M., Holzwarth, B., Kläsener, K., Kuper, I., Boehlke, C., Sonntag, A., Ruf, S., Maerz, L., Nitschke, R., Grellscheid, S., Reth, M., Walz, G., Baumeister, R., Neumann-Haefelin, E., & Thedieck, K. (2015). TSC1 activates TGF-β-Smad2/3 signaling in growth arrest and epithelial-to-mesenchymal transition. Developmental Cell, 32(5), 617-630. https://doi.org/10.1016/j.devcel.2015.01.026
• Zupanic, A., Meplan, C., Grellscheid, S., Mathers, J., Kirkwood, T., Hesketh, J., & Shanley, D. (2014). Detecting translational regulation by change point analysis of ribosome profiling data sets. RNA, 20(10), 1507-1518. https://doi.org/10.1261/rna.045286.114
• Schmid, R., Grellscheid, S., Ehrmann, I., Dalgliesh, C., Danilenko, M., Paronetto, M., Pedrotti, S., Grellscheid, D., Dixon, R., Sette, C., Eperon, I., & Elliott, D. (2013). The splicing landscape is globally reprogrammed during male meiosis. Nucleic Acids Research, 41(22), 10170-10184. https://doi.org/10.1093/nar/gkt811
• Thedieck, K., Holzwarth, B., Prentzell, M., Boehlke, C., Kläsener, K., Ruf, S., Sonntag, A., Maerz, L., Grellscheid, S., Kremmer, E., Nitschke, R., Kuehn, E., Jonker, J., Groen, A., Reth, M., Hall, M., & Baumeister, R. (2013). Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells. Cell, 154(4), 859-874. https://doi.org/10.1016/j.cell.2013.07.031
• Elliott, D., Best, A., Dalgliesh, C., Ehrmann, I., & Grellscheid, S. (2012). How does Tra2β protein regulate tissue-specific RNA splicing?. Biochemical Society Transactions, 40(4), 784-788. https://doi.org/10.1042/bst20120036
• Grellscheid, S., Dalgliesh, C., Storbeck, M., Best, A., Liu, Y., Jakubik, M., Mende, Y., Ehrmann, I., Curk, T., Rossbach, K., Bourgeois, C., Stévenin, J., Grellscheid, D., Jackson, M., Wirth, B., & Elliott, D. (2011). Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development. PLoS Genetics, 7(12), Article e1002390. https://doi.org/10.1371/journal.pgen.1002390
• Rajan, P., Dalgliesh, C., Carling, P., Buist, T., Zhang, C., Grellscheid, S., Armstrong, K., Stockley, J., Simillion, C., Gaughan, L., Kalna, G., Zhang, M., Robson, C., Leung, H., & Elliott, D. (2011). Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome. PLoS ONE, 6(12), Article e29088. https://doi.org/10.1371/journal.pone.0029088
• Grellscheid, S., Dalgliesh, C., Rozanska, A., Grellscheid, D., Bourgeois, C., Stévenin, J., & Elliott, D. (2011). Molecular design of a splicing switch responsive to the RNA binding protein Tra2β. Nucleic Acids Research, 39(18), 8092-8104. https://doi.org/10.1093/nar/gkr495
• Brichta, L., Garbes, L., Jedrzejowska, M., Grellscheid, S., Holker, I., Zimmermann, K., & Wirth, B. (2008). Nonsense-mediated messenger RNA decay of survival motor neuron 1 causes spinal muscular atrophy. Human Genetics, 123(2), 141-153. https://doi.org/10.1007/s00439-007-0455-7
• Skrisovska, L., Bourgeois, C., Stefl, R., Grellscheid, S., Kister, L., Wenter, P., Elliott, D., Stevenin, J., & Allain, F. (2007). The testis-specific human protein RBMY recognizes RNA through a novel mode of interaction. EMBO Reports, 8(4), 372-379. https://doi.org/10.1038/sj.embor.7400910
• Vukusic, I., Grellscheid, S., & Wiehe, T. (2007). Applying genetic programming to the prediction of alternative mRNA splice variants. Genomics, 89((4):), 471-479
• Grellscheid, S., & Smith, C. (2006). An apparent pseudo-exon acts both as an alternative exon that leads to nonsense-mediated decay and as a zero-length exon